Grade 10

Mini Medical School - Hematology

Author(s): Rustom Falahati, Megan Robblee, Bonnie Daley

Mini Medical School - Hematology

This is a two-class lesson plan. During the first class students are entered into a "mini-medical school" where they will learn about the functions and components of blood and make a candy model to reflect their relative proportions.  At the end of the class, they graduate medical school as hematologists. The next day they will be presented with a mock patient with a blood disorder. In groups, they will attempt to diagnose the patient using blood smears, results of lab tests, and patient histories.

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Amylase - Exploring digestion and evolution through a molecular machine

Author(s): Becky Fulop, Juliet Girard, Thomas Noriega

Amylase - Exploring digestion and evolution through a molecular machine

The lesson is designed around two sets of experiments. The first set demonstrates that amylase is a digestive enzyme that degrades starch into sugar, can do so repeatedly and, like many enzymes, is sensitive to acid. The second set of experiments demonstrates the variability of amylase activity in different students' saliva. 

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Exploring chemical bonding

Author(s): SEP staff

Exploring chemical bonding

Students will engage in an exploration demonstrating the Octet rule and chemical bonding using paper models of elements forming covalent and ionic compounds.

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Antigen switching in malaria

Author(s): Mary Kate Alexander

Antigen switching in malaria

In this activity, students will model how the parasitic malaria protist Plasmodium falciparum evades the host immune response through a phenomenon called antigen switching.  Specifically, slips of paper representing malaria-infected red blood cells will be used to demonstrate how random changes in the expression of Plasmodium proteins that display on the surface of human red blood cells helps the parasite avoid destruction by the host immune system.  Students start with a single infected red blood cell with a specific surface marker protein, and from there will simulate the spread of infection through multiple generations of infection (each generation consisting of a parasite infecting a red blood cell, dividing and multiplying inside the red blood cell, then bursting to release new parasites that go on to infect new red blood cells).  Student will find that the parasite occasionally changes the type of surface marker protein expressed over several generations.  When the immune system begins destroying infected cells displaying the original surface protein, cells that have switched to expressing a different protein survive and continue to divide.

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Perception and the Brain

Author(s): Erin Currie, Eirene Markenscoff-Papadimitriou, SEP Staff

Perception and the Brain

In this lesson, students are introduced to how the brain interprets and uses sensory information from the visual system to guide how the body moves and performs various tasks. This lesson makes use of a specialized set of goggles with prism lenses that shift what the wearer sees. Using these prism goggles, students will see first hand how the brain adapts over time to changes in what we perceive. The lesson also makes a connection to the brain and brain function by giving students a chance to see and touch a preserved brain specimen.

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Mini Mystery Boxes

Author(s): SEP Coordinators

Mini Mystery Boxes

This lesson is designed to help students better understand the nature of science. It uses simple, readily available mini-mystery boxes to model how scientists study things they cannot see (see http://www.lab-aids.com/catalog.php?item=100). Scientists often study things that cannot be seen - either because they are incredibly small (inside of cells/atoms) or too far away (other galaxies). In such work, scientists must rely on indirect information. Mystery boxes – each with a small steel ball and a raised terrain inside – demonstrate this aspect of science to participants. The students will draw a model and discuss in groups what they think the box looks like inside.

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Love in the Time of Cholera - Osmosis in action

Author(s): Amy Trusso, Brad Stohr, Stephen Floor, Greg Friedland

Love in the Time of Cholera - Osmosis in action

Students will first learn about the cause of cholera, and propose treatment options to save a hypothetical patient. They will then learn about the osmotic basis of the disease by using a simple dialysis tube/sucrose model for cholera diarrhea. Finally, they will discuss how osmosis can be harnessed to effectively treat the disease and how this treatment has saved millions of lives.

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Mystery Box

Author(s): SEP Coordinators

Mystery Box

This lesson is designed to help students better understand the nature of science. It uses a Mystery Box (see attached photos) which has a funnel at the top and a beaker underneath. When water is poured into the top funnel, colored water flows out the bottom. A turn of the funnel and then pouring in more water results in either a different colored water or no water at all. The teacher demonstrates this Mystery Box to students and challenges them to propose models of the inside of the box. The students draw models of what they think the inside of the box looks like and share and discuss these models. Students can also construct their own mystery box using cardboard boxes and other common materials. For this option, you will need an additional class period.

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Detecting Photosynthesis- Analyzing Other Scientists' Data

Author(s): SEP Staff (Architecture of Life Course)

Detecting Photosynthesis- Analyzing Other Scientists' Data

Students will analyze the results of another scientist's experiment by examining leaves that have been exposed to different treatments, and draw conclusions about the process of photosynthesis.

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Testing for Lipids, Proteins and Carbohydrates

Author(s): SEP staff (Chemistry of Life lesson)

Testing for Lipids, Proteins and Carbohydrates

Students will test a variety of food samples for the presence of lipids, proteins, simple and complex carbohydrates.

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Properties of Metals

Author(s): Philip Merksamer, Beatrice Wang, Sue Mocklin, Sarah Simson

Properties of Metals

Students will be able to see the iron filings in breakfast cereal fortified with iron and qualitatively compare the iron content between 2 different cereals.   They will also see that as part of a salt solution, some elements give off characteristic colors when placed in a flame.

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How does an infectious disease spread? HIV simulation

Author(s): SEP staff

How does an infectious disease spread? HIV simulation

Students will simulate the exchange of bodyfluids and then test whether they got infected with a disease. This activity will show how one person who is infected with a disease can infect other people, who in turn infect others. Students will be able to see how behavior can effect their risk of getting infected.

The lesson plan was inspired by many educators. Thanks to Lance Powell at June Jordan HS in San Francisco, Jennifer Doherty and Dr. Ingrid Waldron, University of Pennsylvania

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Extract your own DNA from cheek cells

Author(s): SEP staff

Extract your own DNA from cheek cells

Students will extract DNA from their own cheek cells.

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